Thursday August 9th
9:00 Welcome
Session 1: Epidemiology and genetics
Chair: Masahito Yamada, John Hardy
09:10
| Yamada
| Masahito
| Cerebral amyloid angiopathy (CAA) and CAA-related disorders: Epidemiology and risk factors
| 09:40
| Hardy
| John
| Whole genome analysis of neurodegenerative
disease. Implications for CAA
| 10:10
| Coffee
| |
| 10:40
| Palsdottir
| Astridur
| Epidemiology of hereditary cystatin C amyloid angiopathy
| 10:55
| Attems
| Johannes
| Intracerebral haemorrhage is not associated
to CAA: An autopsy study on 394 cases
| 11:10
| Kalaria | Rajesh N | Cerebral microhaemorrahges, CAA and stroke
| 11:25 -
13:00
| Lunch
| |
|
Session 2: Clinicical aspects and neuropathology
Chair: Steven M. Greenberg, Harry Winters
13:00
| Greenberg
| Steven M.
| Nature´s fragile vessel: CAA and
microvascular disease
| 13:30
| Vinters
| Harry V.
| CAA: Its significance as a cause of stroke in the elderly
| 14:00
| Boche
| Delphine
| Effects of Ab42 immunotherapy on CAA in human Alzheimer´s disease
| 14:15
| Kirsch
| Wolf M.
| A progressive increase in brain micro-hemorrhages correlating with sporadic late-onset-dementia development
| 14:30
| Coffee
| |
| 15:00
| Thal
| Dietmar R.
| CAA is associated with a reduction of capillary density and with disturbances in cerbral blood flow
| 15:15
| Carare
| Roxana O.
| Pathogenesis of CAA-I: Depostition of amyloid in capillary and artery basement membranes corresponds exactly with interstitial fluid drainage pathways
|
15:30
| Weller
| Roy O.
| Pathogenesis of CAA II: Putative role for age changes in cerebral arteries and cerebrovascular disease
|
Friday August 10th
Session 3: Mouse models and mechanisms
Chair: Mathias Jucker, Efrat Levy
09:00
| Jucker
| Mathias
| Transgenic mouse models of cerebral b-amyloidosis
| 09:30
| Levy
| Efrat
| The role of cystatin C in CAA and stroke
| 10:00
| Coffee
| |
| 10:30
| Ayata
| C.
| Age-dependent cerebrovascular dysfunction in Tg2576 transgenic mouse model of human CAA
| 10:45
| Wilcock
| Donna M.
| NOS2 deletion results in amyloid redistribution and neurovascular changes in two distinct mouse models of amyloid deposition
| 11:00
| Hernandez-Guillamon
| Mar
| Role of matrix metalloproteinases in beta amyloid clearance and degradation
| 11:15
| Yamashita
| Taro
| Liver transplantation reduces cerebral hemorrhage in hereditary CAA amyloid angiopathy associated with amyloidgenic transthyretin Tyr114Cys
| 11:30
| Love
| Seth
| Abnormalities of Ab-degrading enzymes in CAA
| 11:45 -
13:00
| Lunch
| | |
Session 4: Structure and biochemistry
Chair: Anders Grubb, Jorge Ghiso
13:00
| Grubb
| Anders
| Domain swapping: A crucial step in cystatin C amyloid formation
| 13:30
| Ghiso
| Jorge
| Molecular pathogenesis of cerebrovascular amyloidosis
| 14:00
| Jaskolski
| Mariusz
| Crystal structure of human cystatin C stabilized against 3D domain swapping
| 14:15
| Heegaard
| Niels H.H.
| Structural stability of cystatin C in CSF and beta-amyloid peptide (1-40) binding studies of full length deltaN8 -truncated, and gly-mutated cystatin C
| 14:30
| Coffee
| |
|
Special session (organized by J. Rosand)
Sporadic CAA as a complex disease for genetic investigation
15:00
| Stefansson
| Kári
| Successful discovery of complex disease genes
| 15:15
| Van Nostrand
| William E.
| Harnessing genetic discoveries from patients: Cerebral microvascular amyloid promotes microglial activation and behaviorial deficits in a transgenic mouse model of familial CAA
| 15:30
| Van Buchem
| Mark
| Neuroimaging of CAA: Quantitative
phenotypes for genetic analysis
| 15:45
| Rosand
| Jonathan
| Stroke, cognitive impairment, and making anticoagulation safer: Using genetic discoveries to reduce the public health impact of sporadic CAA
|
Poster Blitz
16:00
| Poster Blitz: individual poster presentations, 3 minutes each
|
Satellite meeting
17:00
| Satellite meeting on diagnostic protocols and criteria organized by Kathy Chalmers and coworkers
|
Saturday August 11th
Session 5: Familial forms of CAA
Chair: Marion Maat-Schieman, Astridur Palsdottir
09:00
| Maat-Schieman
| Marion
| Clinical and pathological aspects of hereditary cerebral hemorrhage with amyloidosis- Dutch type (HCHWA-D)
| 09:30
| Blöndal
| Hannes
| Histopathology of hereditary cystatin C amyloidosis
| 10:00
| Coffee
| |
| 10:30
| Coomaraswamy
| Janaky
| Familial British and Danish dementia: What transgenic mouse models can tell us
| 10:45
| Thormodsson
| Finnbogi R.
| The role of vascular smooth muscle cells in HCHWA-I
| 11:00
| Snorradottir
| Asbjorg O.
| Hereditary cystatin C amyloid angiopathy: Study of ECM components in patients´ vessels
| 11:15 –
12:00
| Round table discussion: How much CAA is requried to become symptomatic: how to quantify CAA burden?
| 12:00 –
13:00
| Lunch
| |
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